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We are part of the Department of Biochemistry at the Indian Institute of Science. Our group is working at the interface of biology and physics, focusing on understanding genome organization across all life forms by developing novel imaging tools. Additionally, these imaging tools enable us to understand the fundamentals of biological phenomena.

  • We use state-of-the-art single-molecule techniques to investigate enzymes that copy, protect, and compact our genome. These mechanistic details will be applied to understand the effects of antiviral and antibiotics on enzyme kinetics.
  • We develop multiplexed imaging approaches based on DNA-PAINT super-resolution imaging and apply them to understand cellular organization.

Key publications

  1. Satheesh T. et al., Sequence-dependent co-condensation of Lsr2 with DNA elucidates the mechanism of genome compaction in Mycobacterium tuberculosis, Nucleic Acids Res, 2025
  2. Banerjee A., et al., High-Speed Multiplexed DNA-PAINT Imaging of Nuclear Organization Using an Expanded Sequence Repertoire, Biorxiv, 2025
  3. Shahu S. et al., Bridging DNA contacts allow Dps from E. coli to condense DNA, Nucleic Acids Res, 2024
  4. Banerjee A. et al., Single-Molecule Analysis of DNA Base-Stacking Energetics Using Patterned DNA Nanostructures, Nature Nanotechnology, 2023
  5. Ganji M. et al., Real-time imaging of DNA loop extrusion by condensin, Science, 2018

Openings

No openings are available!